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Decision Resources Webinar

European Clinician and Payer Perspectives on the Dominance of Roche’s MabThera in NHL and CLL – Will Emerging Monoclonal Antibodies Be Able to Compete?

— A Webinar from Decision Resources

Based on our European Physician & Payer Forum report entitled Will Emerging Monoclonal Antibodies Threaten MabThera’s Domination of the Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia Markets in Europe? Clinician and Payer Perspectives, Decision Resources is offering an exclusive webinar entitled European Clinician and Payer Perspectives on the Dominance of Roche’s MabThera in NHL and CLL – Will Emerging Monoclonal Antibodies Be Able to Compete? Because this webinar will feature major findings, it is ONLY available to purchasers of this report.

Please contact us to learn how you can purchase this European Physician & Payer Forum report and attend the webinar.

The current treatment of non-Hodgkin’s lymphoma (NHL) and chronic lymphocytic leukemia (CLL) is characterized by the high uptake of Roche’s MabThera (rituximab). MabThera, an anti-CD20 monoclonal antibody (MAb), has been approved in multiple NHL patient populations and across various lines of treatment. Based on the dramatic clinical and commercial success of MabThera, there is considerable incentive in developing similar MAbs for the treatment of NHL and CLL. Emerging MAbs hoping to enter the NHL and CLL drug-treatable populations face formidable competition from the well-established MabThera and significant penetration into lucrative patient settings is highly challenging. Furthermore, MabThera and emerging MAbs will be threatened by the imminent expected launch of biosimilar versions of rituximab in Europe.

GlaxoSmithKline/Genmab’s Arzerra (ofatumumab) recently received conditional marketing authorization for the treatment of heavily refractory CLL patients and therefore presents the most immediate threat to MabThera’s dominance. Hematologist-oncologists and payers will be forced to consider emerging MAbs and biosimilar rituximab for NHL and CLL over the next several years – ultimately leading to changes in clinical practice in increasingly cost-conscious markets.

Decision Resources surveyed 251 European hematologist-oncologists and interviewed 15 European Payers to assess their attitudes and expectations surrounding current and emerging MAbs for NHL and CLL.

This webinar, presented by Decision Resources Analyst Andrew Merron, Ph.D. will answer the following questions:

  • In NHL, what factors both constrain as well as drive the uptake of MabThera? How can emerging MAbs exploit these opportunities?
  • In NHL and CLL, which MAbs are currently prescribed, and what are their patient shares by line of treatment for NHL subpopulations such as follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL)?
  • What clinical achievements do emerging MAbs need to demonstrate in FL, DLBCL, and CLL in order to oust MabThera from its dominant position? Will emerging MAbs in development meet these requirements? How can emerging MAbs achieve market access without demonstrating superiority over MabThera?
  • What features, mechanisms of action and targets of MAbs are considered most promising by surveyed hematologist-oncologists? Which emerging MAbs fulfill these criteria?
  • In CLL, what will be the impact of the approval of Arzerra on current clinical practice? How will Arzerra be positioned in the clinical setting and what patient share will Arzerra achieve in CLL and off-label in NHL? How will Arzerra launch impact MabThera in NHL and CLL? What is the sales potential for Arzerra by country?
  • Which emerging MAb is considered to be the most promising agent, and which agent is most likely to be prescribed ahead of MabThera?
  • How will the anticipated entry of biosimilar rituximab impact sales of currently available MAbs? What are the safety achievements required in order for hematologist-oncologists to switch between branded and biosimilar MAbs?
  • How do interviewed payers view the emergence of biosimilar versions of rituximab? What is the outlook for novel emerging MAbs in terms of pricing and reimbursement?

Dr. Merron will conduct a live Q & A session after the presentation.

Registration

European Clinician and Payer Perspectives on the Dominance of Roche’s MabThera in NHL and CLL – Will Emerging Monoclonal Antibodies Be Able to Compete?

September 22, 2010 at 10 a.m. U.S. Eastern Time, 4 p.m. Central European Time (Paris).

To learn how you can purchase this Physician & Payer Forum report and attend the webinar, please contact us using the information below.


Contact Us

In North America — Keith Rourke at 781-993-2656 or krourke@dresources.com

In Europe — Kaj van Langendonck at +32-2-357-06-14 or kvanlangendonck@decisionresources.be

In Japan — Makiko Yoshimoto at +81-3-5401-2615 or makiko@dresources.jp

Webinar Details

Date & Time
Wednesday, September 22, 2010
10 a.m. ET, 4 p.m. CET

Presentation: 30 minutes

Q & A: 10 minutes

Learn More!


About the Speaker

Andrew Merron, Ph.D.Andrew Merron, Ph.D., is a senior oncology analyst at Decision Resources. Dr Merron’s research interests and areas of expertise cover hematological malignancies (including lymphoma, leukemia and myeloma) and prostate cancer. Dr. Merron received his Ph.D. in molecular oncology from the University of London. His doctorate focused on in vivo molecular imaging of cancer gene therapies, specifically oncolytic adenoviruses. Prior to obtaining his Ph.D., he earned his B.Sc. in biochemistry from the University of Bath.

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